The debate will be moderated by Brian Williams and the panel will include Tampa Bay Times' editor, Adam Smith.
Only about 500 people are expected
Tonights debate will be held in USF's Marshall Student Center.
The university also expects protestors who oppose “a tax on the 99 percent” they feel is imposed by republicans.
The debate will air on NBC live from 9:00 p.m. to 10:30 p.m.
The debate, featuring Mitt Romney, Rick Santorum, Ron Paul and Newt Gingrich
The debate comes just eight days before Florida Republicans vote in the state's Republican primary to decide which GOP candidate they want to face President Obama in the November general election.